Using state-of-the-art technology, scientists at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen and their international collaborators have successfully obtained molecular snapshots of tens of thousands processes involved in DNA damage repair.
On a daily basis, this restoration keeps cells healthy and prevents the development of cancer. The results of this study will help unravel exactly how cells repair their broken DNA, how chemotherapy affects cells´ workings and will assist in the discovery of new drugs with fewer side effects.
Everything from sun tanning to environmental factors and normal metabolic processes inside the cell damages the DNA of that cell every day. This in turn can lead to production of faulty proteins that - if not repaired - could go on to become the driver of cancer development.
"DNA repair is vital in keeping cells healthy. So unraveling the molecular details of how a cell communicates when its DNA is broken will help us understand how cells protect their genomes," says Associate Professor Chunaram Choudhary from the Novo Nordisk Foundation Center for Protein Research.
DNA repair has been studied intensely for years, but Associate Professor Choudhary and his group at the Department of Proteomics along with his collaborators from University of Cambridge and Max Planck Institute are the first to unravel tens of thousands of molecular signalling events involved in this complex process.